A novel chimeric protein composed of recombinant Mycoplasma hyopneumoniae antigens as a vaccine candidate evaluated in mice

NR de Oliveira, S Jorge, CK Gomes, C Rizzi… - Veterinary …, 2017 - Elsevier
hyopneumoniae antigens: P97R1, P46, P95, and P42. The antigenicity of this construction
… the immune response induced in mice against the chimeric protein delivered via a subunit

A concise review of vaccines against Mycoplasma hyopneumoniae

Y Tao, J Shu, J Chen, Y Wu, Y He - Research in veterinary science, 2019 - Elsevier
… and vaccine inoculation of Mycoplasma hyopneumoniae. … Then, mice that were orally
vaccinated with recombinant … surface antigen precursor P46 and the outer membrane protein P95, …

… systemic immune responses induced by intranasal immunization of recombinant Bacillus subtilis expressing the P97R1, P46 antigens of Mycoplasma hyopneumoniae

Y Wang, J Wang, M Zhou, P Liu, E Zhang… - Bioscience …, 2019 - portlandpress.com
delivery and proved to be effectively enhancing the innate … study, recombinant BS-P97R1
in immunized in mice could … , the P46 protein has been used as subunit or DNA vaccines

[HTML][HTML] Immune responses induced by a combined vaccination with a recombinant chimera of Mycoplasma hyopneumoniae antigens and capsid virus-like particles …

Y Tao, R Yang, J Shu, W Zheng, J Chen, Y Wu… - BMC veterinary …, 2020 - Springer
… the immunization with this combination vaccine in mice and … of the P97R1, P95, P46 and
P42 antigens of Mhp showed good … subunit antigens. The formation of a chimera from fewer …

[HTML][HTML] A Recombinant Chimera Vaccine Composed of LTB and Mycoplasma hyopneumoniae Antigens P97R1, mhp390 and P46 Elicits Cellular Immunologic …

W Liu, P Jiang, T Song, K Yang, F Yuan, T Gao, Z Liu… - Vaccines, 2023 - mdpi.com
… The 46-kDa surface antigen (P46) has been tested as a DNA and subunit vaccine in mice.
The results demonstrated that P46 induced high levels of IgG antibodies and IFN-γ …

[HTML][HTML] Perspectives for improvement of Mycoplasma hyopneumoniae vaccines in pigs

D Maes, F Boyen, B Devriendt, P Kuhnert… - Veterinary …, 2021 - Springer
… /or considered important for adhesion such as P97, P46, P71 and P95. However, also other
… successfully as a vaccine antigen for other pathogens such as Salmonella Typhi in mice and …

[HTML][HTML] Development of a Combined Genetic Engineering Vaccine for Porcine Circovirus Type 2 and Mycoplasma Hyopneumoniae by a Baculovirus Expression …

Y Tao, G Li, W Zheng, J Shu, J Chen, F Yang… - International Journal of …, 2019 - mdpi.com
antigens of Mhp have been identified and used for vaccine development, such as P97R1,
P46, and P42, and genetically engineered vaccines … effects against Mhp antigens in mice. The …

Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation

MR Santos, LT Toledo, ÊJ Bassi, WJN Porto… - Brazilian Journal of …, 2024 - Springer
… ELISA antigens were evaluated in the six immunized groups. IgA antibodies against Mhp
proteins (D). Mice were immunized with recombinant … , namely P97R1, P46, P95, and P42. This …

[PDF][PDF] Evaluation of different innovative bacterins against Mycoplasma hyopneumoniae

A Matthijs - 2019 - biblio.ugent.be
… + and CD8+ T cells by presenting processed antigen linked to major … pulmonis), CD8+ T cell
depleted mice developed more … -specific IgG levels in serum induced by vaccination are not …

[HTML][HTML] Development of a Multi-Epitope Vaccine for Mycoplasma hyopneumoniae and Evaluation of Its Immune Responses in Mice and Piglets

G Li, J Shu, J Jin, J Shu, H Feng, J Chen… - International Journal of …, 2022 - mdpi.com
… combined to produce recombinant proteins MhpMEV and … pathogens can be used as
candidate antigens. In addition, this … was a combination of conserved epitopes rather than subunit